Editorial: sprue-like enteropathy associated with olmesartan - broadening the differential diagnosis of enteropathy

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Severe sprue-like enteropathy associated with olmesartan.

OBJECTIVE To report the response to discontinuation of olmesartan, an angiotensin II receptor antagonist commonly prescribed for treatment of hypertension, in patients with unexplained severe spruelike enteropathy. PATIENTS AND METHODS All 22 patients included in this report were seen at Mayo Clinic in Rochester, Minnesota, between August 1, 2008, and August 1, 2011, for evaluation of unexpla...

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Olmesartan-Induced Sprue Like Enteropathy

Chronic diarrhoea is a common clinical problem in gastroenterology practice and often it is difficult to diagnose the cause. Villous atrophy is not specific and the rarer possibility of drug-induced enteritis should always be considered. Olmesartan has recently been described as a cause of drug-induced enteropathy characterized by chronic diarrhoea and varying degrees of duodenal mucosa atrophy...

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Systematic review: Sprue-like enteropathy associated with olmesartan.

BACKGROUND The onset of a sprue-like enteropathy in association with olmesartan therapy has been recently reported. AIMS To perform a systematic review of the literature and describe three additional cases of olmesartan-associated enteropathy. METHODS Electronic and manual bibliographic searches were performed to identify original reports in which subjects who were undertaking olmesartan de...

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Sprue-Like Enteropathy Associated With Olmesartan: A New Kid on the Enteropathy Block

Sprue-like enteropathy associated with olmesartan, first identified by our group in 2012,1 is characterized by chronic diarrhea (often severe) and weight loss that is unresponsive to a gluten-free diet. Laboratory work-up commonly reveals non-specific anemia, hypoalbuminemia, electrolyte imbalance, and vitamin deficiencies, consistent with a severe malabsorption process. Histopathological findi...

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Sprue-Like Enteropathy Associated with Olmesartan: An Unrecognized Emerging Drug-Induced Enteropathy?

F 72 2014 Chronic diarrhea; abdominal discomfort 6 months Normocytic anemia; hypoK; hypoAlb Clinical remission 3 months Yes features and share our small case-series experience (Table 1). Curiously, in both cases symptoms developed long (fourteen and ten months, respectively) after starting therapy. This has rarely been addressed and may difficult the diagnosis. The primary care physicians were ...

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ژورنال

عنوان ژورنال: Alimentary Pharmacology & Therapeutics

سال: 2014

ISSN: 0269-2813

DOI: 10.1111/apt.13000